"We used NanoSTING as the adjuvant for intranasal vaccination and single-cell RNA-sequencing to confirm the nasal-associated lymphoid tissue as an inductive site upon vaccination. Our results show that the candidate vaccine formulation is safe, produces rapid immune responses -- within seven days -- and elicits comprehensive immunity against SARS-CoV-2," said Varadarajan.
A fundamental limitation of intramuscular vaccines is that they are not designed to elicit mucosal immunity. As prior work with other respiratory pathogens like influenza has shown, sterilizing immunity to virus re-infection requires adaptive immune responses in the respiratory tract and the lung.
The vaccine candidate is easy to administer and it doesn't require refrigeration. This would really be helpful in the global vaccination efforts.
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